May 29, · Creatine is the most effective supplement for increasing muscle mass and strength ().It is a fundamental supplement in the bodybuilding and fitness communities ().Research shows supplementing with. Feb 04, · The primary benefit of creatine is an improvement in strength and power output during resistance exercise. For this purpose, creatine is well-researched, and the effects are quite notable for a supplement. When used in conjunction with resistance exercise, creatine may modestly increase lean . Promote enhanced muscle performance with the amino acid creatine.* Great for more than just athletes – it also supports cellular energy production and cognitive function to help you perform at your best.*.